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Stem Cells
Key Gene Function Against Cell Death Discovered PDF Print E-mail
Wednesday, 23 November 2011 05:15

A team of researchers at the MedUni Vienna's Institute of Medical Genetics has discovered that two genes (TSC/Tuberin and PRAS40) are extremely important regulators in the development of stem cells: if these genes are switched off, the stem cells do not develop but instead die a programmed cell death.

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Recipient's immune system governs stem cell regeneration PDF Print E-mail
Monday, 21 November 2011 07:08

Controlling a stem cell transplant recipient’s immune response may be major key to successful bone regeneration

A new study in Nature Medicine describes how different types of immune system T-cells alternately discourage and encourage stem cells to regrow bone and tissue, bringing into sharp focus the importance of the transplant recipient's immune system in stem cell regeneration.

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Fetal stem cells from placenta may help maternal heart recover from injury PDF Print E-mail
Tuesday, 15 November 2011 05:54

Researchers from Mount Sinai School of Medicine have discovered the therapeutic benefit of fetal stem cells in helping the maternal heart recover after heart attack or other injury. The research, which marks a significant advancement in cardiac regenerative medicine, was presented today at the American Heart Association's (AHA) Scientific Sessions 2011 in Orlando, Florida, and is also published in the current issue of Circulation Research, a journal of the AHA.

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Results triple researchers' projections with use of adult stem cells for heart failure PDF Print E-mail
Monday, 14 November 2011 06:14

Data from UofL trial published today in The Lancet and presented at American Heart Association Scientific Sessions.  

ORLANDO, Fla. – Patients suffering from heart failure due to a previous myocardial infarction showed an average of 12 percent improvement one year following an investigative treatment that involved infusing them with their own stem cells. The results triple the 4 percent improvement average the researchers projected for the Phase I trial.

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Tales from the Crypt: Penn Study on Gut Cell Regeneration Reconciles Long-Standing Research Controversy PDF Print E-mail
Saturday, 12 November 2011 05:44

PHILADELPHIA - The lining of the intestine regenerates itself every few days as compared to say red blood cells that turn over every four months. The cells that help to absorb food and liquid that humans consume are constantly being produced. The various cell types that do this come from stem cells that reside deep in the inner recesses of the accordion-like folds of the intestines, called villi and crypts.

 

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Lung Regeneration Closer to Reality With New Discovery by Weill Cornell Medical College Researchers PDF Print E-mail
Sunday, 30 October 2011 21:41

Study's authors show blood vessels support lung regeneration and their findings could potentially open the door to therapy for lung disorders

Researchers at Weill Cornell Medical College say they have taken an important step forward in their quest to "turn on" lung regeneration — an advance that could effectively treat millions of people suffering from respiratory disorders.

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New Role of Vascular Endothelial Growth Factor in Regulating Skin Cancer Stem Cells PDF Print E-mail
Thursday, 27 October 2011 04:45

One of the key questions in cancer is the identification of the mechanisms that regulate cancer stem cells and tumor growth.

In a study published in Nature, researchers led by Cédric Blanpain, MD/PhD, FNRS/FRS researcher and WELBIO investigator at the IRIBHM, Université libre de Bruxelles, Belgium, in collaboration with the groups of Peter Carmeliet (VIB/K.U.Leuven) and Jody J. Haigh (VIB/UGent) have identified a new role for Vascular Endothelial Growth Factor (VEGF) in regulating skin cancer stem cells.

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Stem Cell Researcher Clones Endangered Coyotes PDF Print E-mail
Thursday, 20 October 2011 00:43

South Korea's once famed stem cell researcher Hwang Woo-suk has successfully cloned endangered coyotes, also known as American jackals, a breakthrough that could help other species or even bring back extinct animals.

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Heart Stem Cell Developer Tops WSJ's Innovation Awards PDF Print E-mail
Thursday, 20 October 2011 00:36
Laboratory generation of billions of heart cells edged out other promising technological innovations this year—such as improvements in biofuel production and IBM’s supercomputer, Watson—as the healthcare entry took top honors in the Wall Street Journal’s (WSJ) 2011 Technology Innovation Awards.
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Precision With Stem Cells a Step Forward for Treating Multiple Sclerosis, Other Diseases PDF Print E-mail
Tuesday, 18 October 2011 00:07
Scientists have improved upon their own previous world-best efforts to pluck out just the right stem cells to address the brain problem at the core of multiple sclerosis and a large number of rare, fatal children's diseases.
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A first -- lab creates cells used by brain to control muscle cells PDF Print E-mail
Wednesday, 23 November 2011 04:04

University of Central Florida researchers, for the first time, have used stem cells to grow neuromuscular junctions between human muscle cells and human spinal cord cells, the key connectors used by the brain to communicate and control muscles in the body.

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Stem Cell Researchers Uncover Mechanism That Regulates Human Pluripotent Stem Cell Metabolism PDF Print E-mail
Thursday, 17 November 2011 07:03

Human pluripotent stem cells, which can develop into any cell type in the body, rely heavily on glycolysis, or sugar fermentation, to drive their metabolic activities. 

In contrast, mature cells in children and adults depend more on cell mitochondria to convert sugar and oxygen into carbon dioxide and water during a high energy-producing process called oxidative phosphorylation for their metabolic needs.

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Delayed stem cell therapy following heart attack is safe but not effective PDF Print E-mail
Monday, 14 November 2011 06:23

NIH-funded trial shows that therapy with bone-marrow derived cells does not improve heart function after six months; Future clinical benefits still possible

NIH-funded trial shows that therapy with bone-marrow derived cells does not improve heart function after six months; future clinical benefits still possible.

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Suicide Switch PDF Print E-mail
Sunday, 13 November 2011 05:15

Inserted gene may improve safety of cell therapies by halting potentially deadly reactions.

Transplanted stem cells can cure patients with leukemia, lymphoma and rare genetic disorders but such procedures can trigger a potentially deadly response known as graft-versus-host disease as the immune cells that the transplanted cells give rise to can attack the patient’s healthy tissue.

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'Mini' Stem Cell Transplant May Help Seniors With Blood Cancer PDF Print E-mail
Thursday, 03 November 2011 07:30

Age in itself should not be a factor in deciding whether blood cancer patients are candidates for stem cell transplantation, according to a new study.

Blood cancers include leukemia, lymphoma and myeloma.

For the study, researchers analyzed long-term outcomes among 372 blood cancer patients aged 60 to 75 who underwent a "mini-transplant," which is a "kinder, gentler" form of allogeneic (cells from another person) stem cell transplantation developed at the Fred Hutchinson Cancer Research Center in Seattle.

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A*STAR scientists first to identify stem cell key to lung regeneration PDF Print E-mail
Friday, 28 October 2011 06:29

Working together, scientists and clinicians make research breakthrough that paves the way for novel therapies for respiratory diseases

Scientists at A*STAR'S Genome Institute of Singapore (GIS) and Institute of Molecular Biology (IMB), have made a breakthrough discovery in the understanding of lung regeneration. Their research showed for the first time that distal airway stem cells (DASCs), a specific type of stem cells in the lungs, are involved in forming new alveoli to replace and repair damaged lung tissue, providing a firm foundation for understanding lung regeneration.

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Lab-Made Skin Cells Will Aid Transplantation, Cancer, Drug Discovery Research, Say Scientists PDF Print E-mail
Thursday, 27 October 2011 04:15

http://pathology.uphs.upenn.edu/Faculty/image.aspx/id/32140.jpgThe pigmented cells called melanocytes aren't just for making freckles and tans. Melanocytes absorb ultraviolet light, protecting the skin from the harmful effects of the sun. They also are the cells that go haywire in melanoma, as well as in more common conditions as vitiligo and albinism.

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UWA Discovers 'Ethical' Embryonic-like Stem Cells In Breast Milk PDF Print E-mail
Thursday, 20 October 2011 00:39

Serious and fatal diseases such as pancreatic cancer, Parkinson's disease and diabetes may eventually be treated using stem cells from breast milk, researchers from the University of Western Australia have discovered.

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More Surgery in Early-Stage Laryngeal Cancer Treatment; More Chemoradiation for Advanced-Stage Patients PDF Print E-mail
Wednesday, 19 October 2011 00:13

The use of surgery to treat early-stage laryngeal cancer (cancer of the voice box) is increasing in the United States, and chemotherapy in combination with radiation therapy is being used increasingly to treat patients in an advanced stage of the disease, according to a report in the October issue of Archives of Otolaryngology -- Head & Neck Surgery, one of the JAMA/Archives journals.

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Understanding the Beginnings of Embryonic Stem Cells Helps Predict the Future PDF Print E-mail
Tuesday, 18 October 2011 00:06
Scientists have shown that laboratory-grown cells express a protein called Blimp1, which represses differentiation to somatic or regular tissue cells during germ cell development. Studies of these cells show that they also express other genes associated with early germ cell specification.
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