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Stem Cells
'Mini' Stem Cell Transplant May Help Seniors With Blood Cancer PDF Print E-mail
Thursday, 03 November 2011 07:30

Age in itself should not be a factor in deciding whether blood cancer patients are candidates for stem cell transplantation, according to a new study.

Blood cancers include leukemia, lymphoma and myeloma.

For the study, researchers analyzed long-term outcomes among 372 blood cancer patients aged 60 to 75 who underwent a "mini-transplant," which is a "kinder, gentler" form of allogeneic (cells from another person) stem cell transplantation developed at the Fred Hutchinson Cancer Research Center in Seattle.

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A*STAR scientists first to identify stem cell key to lung regeneration PDF Print E-mail
Friday, 28 October 2011 06:29

Working together, scientists and clinicians make research breakthrough that paves the way for novel therapies for respiratory diseases

Scientists at A*STAR'S Genome Institute of Singapore (GIS) and Institute of Molecular Biology (IMB), have made a breakthrough discovery in the understanding of lung regeneration. Their research showed for the first time that distal airway stem cells (DASCs), a specific type of stem cells in the lungs, are involved in forming new alveoli to replace and repair damaged lung tissue, providing a firm foundation for understanding lung regeneration.

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Lab-Made Skin Cells Will Aid Transplantation, Cancer, Drug Discovery Research, Say Scientists PDF Print E-mail
Thursday, 27 October 2011 04:15

http://pathology.uphs.upenn.edu/Faculty/image.aspx/id/32140.jpgThe pigmented cells called melanocytes aren't just for making freckles and tans. Melanocytes absorb ultraviolet light, protecting the skin from the harmful effects of the sun. They also are the cells that go haywire in melanoma, as well as in more common conditions as vitiligo and albinism.

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UWA Discovers 'Ethical' Embryonic-like Stem Cells In Breast Milk PDF Print E-mail
Thursday, 20 October 2011 00:39

Serious and fatal diseases such as pancreatic cancer, Parkinson's disease and diabetes may eventually be treated using stem cells from breast milk, researchers from the University of Western Australia have discovered.

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More Surgery in Early-Stage Laryngeal Cancer Treatment; More Chemoradiation for Advanced-Stage Patients PDF Print E-mail
Wednesday, 19 October 2011 00:13

The use of surgery to treat early-stage laryngeal cancer (cancer of the voice box) is increasing in the United States, and chemotherapy in combination with radiation therapy is being used increasingly to treat patients in an advanced stage of the disease, according to a report in the October issue of Archives of Otolaryngology -- Head & Neck Surgery, one of the JAMA/Archives journals.

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Understanding the Beginnings of Embryonic Stem Cells Helps Predict the Future PDF Print E-mail
Tuesday, 18 October 2011 00:06
Scientists have shown that laboratory-grown cells express a protein called Blimp1, which represses differentiation to somatic or regular tissue cells during germ cell development. Studies of these cells show that they also express other genes associated with early germ cell specification.
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New Way to Screen for Brain Cancer Stem Cell Killers PDF Print E-mail
Saturday, 15 October 2011 00:54

Researchers with UCLA's Jonsson Comprehensive Cancer Center have developed and used a high-throughput molecular screening approach that identifies and characterizes chemical compounds that can target the stem cells that are responsible for creating deadly brain tumors.

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Clean Correction of a Patient's Genetic Mutation: New Gene Therapy Methods Accurately Correct Mutation in Patient's Stem Cells PDF Print E-mail
Saturday, 15 October 2011 00:48
For the first time, scientists have cleanly corrected a human gene mutation in a patient's stem cells. The result, reported Oct. 12 in the journal Nature, brings the possibility of patient-specific therapies closer to becoming a reality.
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Distinct Types of Stem Cells Contribute to Mammary Gland Development and Maintenance PDF Print E-mail
Thursday, 13 October 2011 00:28

One of the key questions in biology is the identification of stem cells responsible for tissue morphogenesis and regeneration.

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Expression of Pluripotency-Associated Gene Marks Many Types of Adult Stem Cells PDF Print E-mail
Tuesday, 11 October 2011 00:24
Investigators at the Massachusetts General Hospital (MGH) Center for Regenerative Medicine and the Harvard Stem Cell Institute (HSCI) have found that Sox2 -- one of the transcription factors used in the conversion of adult stem cells into induced pluripotent stem cells (iPSCs) -- is expressed in many adult tissues where it had not been previously observed.
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Lung Regeneration Closer to Reality With New Discovery by Weill Cornell Medical College Researchers PDF Print E-mail
Sunday, 30 October 2011 21:41

Study's authors show blood vessels support lung regeneration and their findings could potentially open the door to therapy for lung disorders

Researchers at Weill Cornell Medical College say they have taken an important step forward in their quest to "turn on" lung regeneration — an advance that could effectively treat millions of people suffering from respiratory disorders.

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New Role of Vascular Endothelial Growth Factor in Regulating Skin Cancer Stem Cells PDF Print E-mail
Thursday, 27 October 2011 04:45

One of the key questions in cancer is the identification of the mechanisms that regulate cancer stem cells and tumor growth.

In a study published in Nature, researchers led by Cédric Blanpain, MD/PhD, FNRS/FRS researcher and WELBIO investigator at the IRIBHM, Université libre de Bruxelles, Belgium, in collaboration with the groups of Peter Carmeliet (VIB/K.U.Leuven) and Jody J. Haigh (VIB/UGent) have identified a new role for Vascular Endothelial Growth Factor (VEGF) in regulating skin cancer stem cells.

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Stem Cell Researcher Clones Endangered Coyotes PDF Print E-mail
Thursday, 20 October 2011 00:43

South Korea's once famed stem cell researcher Hwang Woo-suk has successfully cloned endangered coyotes, also known as American jackals, a breakthrough that could help other species or even bring back extinct animals.

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Heart Stem Cell Developer Tops WSJ's Innovation Awards PDF Print E-mail
Thursday, 20 October 2011 00:36
Laboratory generation of billions of heart cells edged out other promising technological innovations this year—such as improvements in biofuel production and IBM’s supercomputer, Watson—as the healthcare entry took top honors in the Wall Street Journal’s (WSJ) 2011 Technology Innovation Awards.
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Precision With Stem Cells a Step Forward for Treating Multiple Sclerosis, Other Diseases PDF Print E-mail
Tuesday, 18 October 2011 00:07
Scientists have improved upon their own previous world-best efforts to pluck out just the right stem cells to address the brain problem at the core of multiple sclerosis and a large number of rare, fatal children's diseases.
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Stem Cells from Cord Blood Could Help Repair Damaged Heart Muscle PDF Print E-mail
Tuesday, 18 October 2011 00:05
New research has found that stem cells derived from human cord blood could be an effective alternative in repairing heart attacks.

At least 20 million people survive heart attacks and strokes every year, according to World Health Organisation estimates, but many have poor life expectancy and require continual costly clinical care.

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Stem Cells, Signaling Pathways Identified in Lung Repair PDF Print E-mail
Saturday, 15 October 2011 00:52
Researchers at National Jewish Health have identified cells and signaling molecules that trigger the repair of injured lungs. Stijn De Langhe, PhD, and his colleagues report October 10, 2011, online in the Journal of Clinical Investigation, that destruction of lung tissue in mice induces smooth muscle cells surrounding the airways to secrete a protein known as fibroblast growth factor 10 (FGF10), which induces surviving epithelial cells in the airways to revert to a stem-cell state, proliferate, repair and repopulate the lining of the lungs.
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Seeking Superior Stem Cells: 100-Fold Increase in Efficiency in Reprogramming Human Cells to Induced Stem Cells PDF Print E-mail
Thursday, 13 October 2011 00:46
Researchers from the Wellcome Trust Sanger Institute have announced a new technique to reprogram human cells, such as skin cells, into stem cells. Their process increases the efficiency of cell reprogramming by one hundred-fold and generates cells of a higher quality at a faster rate.
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Cell Transformation from One Type of Cell to Another PDF Print E-mail
Tuesday, 11 October 2011 00:25
Researchers from the Haematopoietic Differentiation and Stem Cell Biology group at the Centre for Genomic Regulation (CRG), have described one of the mechanisms by which a cell (from the skin, for example) can be converted into another which is completely different (e.g., a neuron or hepatic cell). They have discovered that the cell transcription factor C/EBPa is a determinant factor in cell transdifferentiation.
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Patient-Specific Stem Cells: Major Step Toward Cell-Based Therapies for Life-Threatening Diseases PDF Print E-mail
Tuesday, 11 October 2011 00:22
A team of scientists led by Dieter Egli and Scott Noggle at The New York Stem Cell Foundation (NYSCF) Laboratory in New York City has made an important advance in the development of patient-specific stem cells that could impact the study and treatment of diseases such as diabetes, Parkinson's, and Alzheimer's.
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